Home Entertainment company Johnson & Johnson recall causes sharp increase in immune response, company says

Johnson & Johnson recall causes sharp increase in immune response, company says


By Maggie Fox | CNN

Booster doses of Johnson & Johnson’s single-dose coronavirus vaccine generated a surge in antibodies, the immune system’s first-line defenses against infection, the company reported on Wednesday.

People who were boosted six to eight months after their initial injections of J&J saw nine times more antibodies than 28 days after the first injection, Johnson & Johnson said.

The data comes from two Phase 2 studies conducted in the United States and Europe, the company said in a statement. Some of the approximately 2,000 people in the studies received booster doses six months after their first doses of J & J’s Janssen vaccine.

“New interim data from these studies demonstrates that a booster dose of Johnson & Johnson COVID-19 vaccine generated a rapid and robust increase in spike binding antibodies, nine times greater than 28 days after primary dose vaccination unique, ”the company said in its statement.

“We have established that a single injection of our COVID-19 vaccine generates strong and robust immune responses that are long-lasting and persistent for eight months. With this new data, we also see that a booster dose of the Johnson & Johnson COVID-19 vaccine further increases antibody responses in study participants who had previously received our vaccine, ”Dr Mathai Mammen, Global Head of research and development for Janssen, said in a statement.

J&J said he is in discussions with the United States Food and Drug Administration, the United States Centers for Disease Control and Prevention, the European Medicines Agency, the World Health Organization and others. health authorities on the need to offer a booster dose of the Janssen vaccine.

“We look forward to discussing with public health officials a potential strategy for our Johnson & Johnson COVID-19 vaccine, increasing eight months or more after primary single-dose vaccination,” Mammen added.

Many people who have received the J&J vaccine are asking for information on whether they will need a booster. U.S. federal government officials said they were preparing to begin offering a booster dose to people who received the Covid-19 vaccine from Moderna or Pfizer after data showed that boosters may amplify the response by antibodies – and after studies began to show an increase in infections in both vaccinated and unvaccinated people. The more transmissible Delta variant is partly to blame, experts say, as is the waning immune response.

The Janssen vaccine was authorized at the end of February, more than two months after the authorization of the Moderna and Pfizer vaccines. About 14 million Americans have received the J&J vaccine, according to the CDC.

Dr Dan Barouch, a vaccine researcher at Beth Israel Deaconess Medical Center and Harvard Medical School, who is not involved in the two clinical studies but helps study J&J vaccines, said the results support obtaining a reminder, but only after a delay.

“The six-month boost is going to look very impressive and significantly better than what has already been reported in terms of the two-month boost, and that’s important because, in my opinion, the boost shouldn’t be. be two months away, but it really should be six months or later, ”Barouch told CNN.

None of the studies looked at real-world effectiveness, so the company hasn’t shown that people who get boosters will be less likely to be infected or develop serious illness. But researchers are starting to agree that antibody levels indicate immune protection.

The Johnson & Johnson vaccine is manufactured differently from those of Pfizer and Moderna. Both of these vaccines use messenger RNA or mRNA, enclosed in small lipid particles, to send instructions to the body to trigger an immune response.

The Janssen vaccine uses a paralyzed cold virus called adenovirus to be carried in similar instructions. It was feared that a booster dose of such a viral vector vaccine would not work effectively due to the possibility that the body would also generate an immune response against the vector.

“There was a theoretical fear that the generation of anti-vector antibodies by the first shot could hamper its use again,” said Barouch.

“I think this data puts that aside.”

Federal health officials have said they believe a booster dose of the Janssen vaccine will be needed at some point.

“I have every confidence that the FDA, CDC, NIH, and the White House will use this data to likely justify or recommend a booster for people vaccinated against J&J, possibly with a second injection of J&J,” Barouch said.

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